Over the past two decades, it has become increasingly clear that, broadly speaking, schizophrenia is likely an illness resulting from the cumulative effects of multiple risk factors, both both genetic and environmental. In the general population, the lifetime risk of developing schizophrenia is approximately 1% [1], the greatest risk identified being a positive family history of the disease: in a person with a first-degree relative, the risk increases by up to 10%, rises to 40% in identical twins of individuals with schizophrenia [2], and is highest at 48% in people where both parents have the illness [3]. . Twin and adoption studies have shown that this risk is primarily genetic, although some environmental or developmental factors also appear to confer risk given that members of the general population can still develop schizophrenia in the absence of a history. family of the disease [4-8]. Obstetric complications, maternal infection during pregnancy, urban delivery, delivery later in winter or early spring, immigration status, and adverse life events have all been associated with risk increased risk of developing schizophrenia, even if one of them is an occasional, independent or perhaps risk factor. whether it is the result of another underlying factor causing the changes observed in schizophrenia is still unknown[9]. Because patients with psychosis are more likely to abuse cannabis than the rest of the general population, cannabis use has long been considered an occasional risk factor for the development of schizophrenia.[10] The purpose of this article is to review and discuss the epidemiological, neuropharmacological, and neurodevelopmental evidence for this hypothesis. The relationship between humans and the psychoactive plant Cannabi...... middle of article...... must be protective against the negative symptoms of schizophrenia (possibility of increasing the rate of self-medication), Further research into the specific agent in cannabis that produces this effect would be beneficial in understanding the complex nature between cannabis and schizophrenia. Cannabidiol (CBD), a component of cannabis that appears to have some antipsychotic properties, appears to be an interesting target for such research, and further studies on the long-term prognosis of cannabis users with schizophrenia may want to see what role this plays. plays this molecule. with THC to modulate symptoms. As the public debate in the United States debates the possible decriminalization of cannabis use, it is perhaps more necessary than ever for clearer answers about the impact of cannabis use on people at risk. risk of developing chronic psychotic disorders..