Several studies have documented that lifestyle intervention is the solution capable of reducing body weight in obese people. The Diabetes Prevention Program4 compared the percentage of weight loss by giving a lifestyle intervention, placebo, and metformin to obese people. The result indicates that after four years, a lifestyle intervention, which combines diet modification, physical activity and behavioral therapy, results in 58% more significant weight loss compared to placebo and 39 % compared to metformin. In the Look AHEAD10 study, she looked at the effect of intensive lifestyle modification on people with obesity and type 2 diabetes. After one year, those who underwent intensive lifestyle modification lost weight up to 8.6% compared to their initial weight. It is observed11 that weight loss of up to 7% of body weight can reduce the risk of developing type 2 diabetes by more than 55%. Physical activity also makes an important contribution to weight loss in obese and diabetic people. Continuous low-intensity exercise training can improve fat oxidation by 44%, while moderate-to-high-intensity exercise training is more beneficial for increasing insulin sensitivity.12 In a cohort study, l Daily physical activity, such as walking, can reduce the risk of type 2 diabetes. Finnish Diabetes Prevention found that walking 2.5 hours per week can reduce the incidence of diabetes by 63-69%.13 Weight loss is the result of changing diet and physical activity if they produce an energy deficit. After losing weight, it is crucial to maintain the reduced weight in order to avoid weight regain. Behavioral therapy plays an important role in weight control. It prevents weight regain by creating goal setting, self-monitoring, and stimulus control.9 National Heart, Lung, and Blood I...... middle of paper...... i/full/10.1056/NEJMoa031049.19. Lovejoy J, DiGirolamo M. Usual dietary intake and insulin sensitivity in lean and obese adults. Am J Clin Nutr [Internet]. June 1992 [cited February 7, 2014]; 55(6): 1174-9. Available at: http://ajcn.nutrition.org/content/55/6/1174.full.pdf.20. Shaibi GQ, Roberts CK, Goran MI. Exercise and insulin resistance in youth. Exercise Sport Sci Rev [Internet]. 2008 [cited February 7, 2014]; 36(1): 5-11. Available at: http://www.medscape.com/viewarticle/568391.21. Colberg SR, Sigal RJ, Fernhall B, et al. Exercise and type 2 diabetes. Diabetes care. December 2010; 33(12): e147-e167. doi: 10.2337/dc10-9990.22. Sumithran P, Prendergast LA, Delbridge E et al. Long-term persistence of hormonal adaptations to weight loss. N English J Med [Internet]. October 27, 2011 [cited February 5, 2014]; 365: 1597-1604. Available at: http://www.nejm.org/doi/full/10.1056/NEJMoa1105816