Quijano #342SLPHypertriglyceridemiaIntroductionHypertriglyceridemia is a disease characterized by an alarming concentration of triglycerides in the blood. Triglycerides or triacylglycerol are a lipid formed by esterification of three fatty acids into a glycerol molecule. It is a type of fat found in the blood. When it comes to diet discussions, the term "fat" is usually used to replace triacylglycerol. The normal level of triglycerides in the blood is <150 mg/dl, people with hypertiglyceridemia have a triglyceride level > 150 mg/dl. Mild hypertriglyceridemia – 150-199 mg/dl, Moderate hypertriglyceridemia – 200-999 mg/dl, Severe hypertriglyceridemia – 1000-1999 mg/dl and very severe hypertriglyceridemia – > 2000 mg/dl. There are two main sources of plasma triglycerides. Exogenous sources (from dietary fat) transported in chylomicrons and endogenous (from the liver) transported in very low density lipoproteins. Hypertriglyceridemia is a risk factor for cardiovascular disease and pancreatitis. More importantly, hypertriglyceridemia is usually accompanied by other lipid abnormalities and coronary artery disease-related metabolic syndrome. Classification Main causes of hypertriglyceridemia Familial hypertriglyceridemia is a condition defined by isolated very low density lipoprotein, which is not as rich in triglycerides as chylomicrons. This type of disorder has a prevalence of 5 to 10% in the population. Although the molecular basis of this disorder is still unknown, it is likely that it is polygenic, meaning that it requires a secondary factor for its expression. Combined hyperlipoproteinemia has a population prevalence of 2 to 5%. Abnormalities associated with this disease are increased very low density lipoproteins (VLDL)...... middle of paper ......s added. These are all additive interventions and most of them appear to work by increasing the clearance of triglyceride-rich particles. Works Cited Kwiterovich, P, O. (Ed). (2010). The Johns Hopkins Handbook of Dyslipidemia. United States: Lippincott Williams & Wilkins. O'Riordan, M. (September 10, 2012) New clinical guidelines for the treatment and screening of hypertriglyceridemia. Medical landscape. Retrieved March 1, 2014 from http://www.medscape.com/viewarticle/770655.Pejic, R. (2006). Hypertriglyceridemia. Medical landscape. Retrieved March 1, 2014 from http://www.medscape.com/viewarticle/532511_4.Stroes, ES and Vissers, MN (2010). Evidence-based management of lipid disorders. United Kingdom: Gutenberg Press Ltd. Yuan, G. (April 2007). Hypertriglyceridemia: its etiology, effects and treatment. Journal of the Canadian Medical Association. Accessed March 1, 2014 from http://www.cmaj.ca/content/176/8/1113.full.