Often, naturalists discover scientific discoveries without intending to do so. Dr. Alexander Fleming's curiosity prompted him to isolate and study mold from contaminated influenza culture samples. The tests he conducted to understand the mold, which he would later classify as belonging to the genus penicillium, were open-minded and neutral as he sought to understand what the mold was and why it was deadly to flu culture. (“Accidental Discoveries”) My personal acquisition of knowledge in the natural sciences at school was a similar experience. Not knowing certain aspects of chemistry for example, periodicity, meant that at the beginning, when I asked for explanations, they were open and neutral questions because I had no prior knowledge of the subject. After studying the topic for a while, my questions were closed-ended questions asked to confirm my hypotheses about possible explanations. So I think neutral questions exist in the natural sciences, because when exploring a new topic, scientists should be as impartial as possible. However, it becomes very difficult to ask neutral questions when they are familiar with the domain, as they have prior knowledge of the domain.