Unbeknownst to us, there is a persistent disparity that threatens the very existence of humanity. Something that does not yet exist poses a threat to the continuation of human existence as we know it. The unpredictable outbreak of a strain of avian influenza (bird flu) is the primary concern of public health professionals and health care administrators. The danger of a potential humanized strain of avian influenza outbreak is entirely uncertain, in part because of the impact the ecosystem plays on the diversity of viruses and the evolutionary structure of bacteria. Although enthusiastic research suggests that the outbreak of avian flu is unlikely within our generation, it is nevertheless essential to remain vigilant. The first appearance of bird flu is believed to have appeared in 1878 in northern Italy when Perroncito demonstrated a contagious disease. of poultry associated with high mortality (Lupiani & Reddy, 2009). Avian influenza was later defined by Perroncito as “bird plague”, an acute contagious disease of poultry and other domestic and wild birds (Alexander & Brown, 2009). Highly pathogenic avian influenza became endemic in Italy and central Europe until it disappeared around the mid-1930s (Lupiani & Reddy, 2009). It was not until 1918 that this highly pathogenic flu reached the United States. In 1918, the United States and most of the world lived in fear of an invisible enemy who was rumored to be destroying everything in its path. It was determined that the 1918 influenza epidemic killed more people than the number of deaths achieved during World War I. One-fifth of the world's population was attacked by the deadly 1918 pandemic influenza virus, killing...... article...... immunology, microbiology and infectious diseases, 32(4), 311-323. Merrill, R. M. (2013). Introduction to epidemiology. Jones & Bartlett Publishers. Peiris, J.M., De Jong, M.D., and Guan, Y. (2007). Avian influenza virus (H5N1): a threat to human health. Clinical Microbiology Reviews, 20(2), 243-267.Sfakianos. JN and Alcamo, IE (2006). Avian flu. InfobasePublishing. Wagner, R. Feldmann, A., Wolff, T., Pleschka, S., Garten, W. and Klemk, H.D. (2002). The role of hemagglutinin and neuraminidase in influenza virus pathogenicity, in structure-function relationships of human pathogenic viruses (pp. 331-345). Springer US. World Health Organization. (2013, December). Influenza at the human-animal interface. Retrieved from http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_16December13.pdf