Neisseria gonorrhoeae, also known as gonococci, is a Gram-negative, immobile, non-sporulating, aerobic diplococci that is spread by sexual contact2. It is a human pathogen that is transmitted directly from person to person, usually through mucous membranes1. Infection of the fetus by vertical transmission is possible1. This organism is relatively fragile, making it extremely sensitive to temperature changes, drying, UV rays and other environmental stresses2. Neisseria gonorrhoeae has the many typical components of a Gram-negative outer membrane such as proteins, phospholipids and lipopolysaccharides (LPS)2. However, Neisserial LPS is often referred to as lipooligosaccharide (LOS) due to its highly branched basal oligosaccharide structure with the absence of repetitive O2 antigen subunits. The LOS expressed by Neisseria gonorrhoeae contributes to playing a role in the pathogenesis of this bacterium2. The most common infection caused by Neisseria gonorrhoeae is gonorrhea, also known as "clap." 4. Gonorrhea is a common sexually transmitted infection that can occur in both men. and females. Infection is spread through participation in unprotected sexual intercourse with infected people4. Infection is more common in women, as women who have unprotected sex with infected men have a 50-60% chance of contracting the infection, while men who have sex with infected women have only a 20% chance of contracting the infection9. . Transmission of the disease occurs through direct contact with the mucous membrane exudates of infected individuals5. The bacteria then attach to and penetrate the simple columnar epithelium, producing inflammatory responses in the affected area. With the use of p...... middle of paper ......group of antibiotics like penicillin; it therefore acts by interfering with the ability of bacteria to form cell walls7. The cell wall of bacteria is essential for their survival and, thanks to ceftriaxone forming holes in the cell walls of bacteria, the number of bacteria also begins to decrease7. Finally, azithromycin is a type of antimicrobial that also works by interfering with the ability of bacteria to form proteins essential for their survival8. As antimicrobial resistance slowly begins to increase for the treatment of gonorrhea, it is important that everyone receiving treatment takes antimicrobials effectively and ensures that they take all medications prescribed by their doctor8. There is no vaccine for gonorrhea today, but if you take proper precautions and treatment, if necessary, the bacteria can be controlled.3.