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  • Essay / Multiple Sclerosis - 577

    Multiple sclerosis is a complex autoimmune disease caused by damage to the fatty myelin sheaths around axons in the brain and spinal cord, leading to demyelination, damage (scarring) ) and inflammation1, 2, 3. Damage leads to disruption of nerve impulses along axons, leading to the many symptoms seen in patients with multiple sclerosis. Although its exact etiology is unknown, current research indicates that multiple sclerosis is a complex combination of genetic and environmental factors. It has been established that multiple sclerosis is not hereditary, but research focuses on genetic influence and susceptibility3. Like many other diseases whose etiology has genetic components, the disease risk linked to multiple sclerosis can be calculated on the basis of genetic analyzes looking for certain genetic markers or combinations of markers4. Recent studies show that polymorphisms in the interleukin-2 (IL2)/interleukin-2 receptor alpha (IL2RA)1 pathway and in the interleukin-7 (IL7)/interleukin-2 receptor alpha (IL2RA)1 pathway interleukin-7 alpha (IL7RA)2 are linked to increased risk and susceptibility. of several sclera...